Epigenetic’s Science is written by award winning author, Raoul Pedretta. Great bye, genetically encoded genes… the first book in the exciting new field of epigenetic biology for general readers. The surging new science of epigenetic genetics provides a veritable cornucopia of new insights into our own bodies and minds – some unsettling, some comforting. The premise of Epigenetic’s Science is the fact that environmental exposures can have long lasting effects on cellular function. Some of these effects aren’t so easy to reverse and the authors describe how”epigenetic inheritance” can lead to such disorders as cancer, Alzheimer’s disease and Parkinson’s. They also clarify the surprising effect of”epigenetic pollution,” environmental contaminants that are not detected by regular testing and that can cause severe health problems.
Like all living systems, cells are constantly changing and grow, divide and die. All cells need a continuous supply of energy, and this procedure is initiated by a process called”mimetic induction”. Through natural selection, positive mutations accumulate over generations, and when they get together, these cells form a sort of cellular memory, or methylation state. This methylation state is passed on between generations and decides how cells in one family will behave in response to environmental challenges and how those cells will react when similar challenges arise in a different family member.
When methylation is induced in a cell, the result can be a whole gamut of changes on the cell surface and in the biochemical pathways inside the cell. This results in alterations in gene function and a corresponding response on the body. There are many ways that Epigenetic’s Science presents the science of Epigenetics. For example, each chapter includes an informative section covering among the most frequent Epigenetic changes that occur in all people: puberty. The chapters comprise;”Growthal Sensitivity,””Mutations at Birth,”” hormonal changes,””perinatal development,””adolescent-onset diabetes,” and”nutrition.” I enjoyed each of these and found them to be very interesting and educational.
As you know, during adolescence, the body increases its production of estrogen (in anticipation of future pregnancy), and then, produces DHT (which stands for”dihydrotestosterone”). DHT then binds to the hair follicles, making it difficult for nutrients to reach the roots. This causes baldness in a condition known as”male pattern baldness” Interestingly, this is not the only cause of hair loss, as there are other genetic and environmental factors that contribute to hair loss. Epigenetic science goes a step further and suggests that these other causes of hair loss may also be affected by methylation, so future research may shed more light on Epigenetic’s Science.
The next topic that Epigenetic’s Science touches on is the impact that diet has on the body. Specifically, Epigenetic’s Science goes into detail concerning the impact that diet has on mice, worms, and other organisms. To begin with, one interesting finding was that when the worm C. elegans has been given a high fat diet, it became diabetic and obese. Interestingly, the laboratory animals also lost muscle mass, which is suggestive of insulin resistance. In another experiment, the lab animals were put on a special sort of diet where they only received food which contained carbohydrates; they lost body weight fairly rapidly.
In order to understand what is happening here, you have to have a look at the Epigenetic’s Science methodology. Fundamentally, they are growing yeast in lab cultures and watching what happens. When the yeast grows to a certain point, it will replicate and thus create a new generation of yeast cells. In cases like this, the creation of cells was used to study insulin resistance, something that we humans have.
Needless to say, there are additional Epigenetic’s Science techniques they use, such as gene regulation and the analysis of cancerous tumors. In fact, they have recently established a successful clinical trial where they are trying to treat Alzheimer’s disease in mice. As exciting as that may sound, it is not your regular normal cancer therapy. This study shows they are able to manipulate and regulate cells and stop the growth of cancerous tumors.
Besides diabetes, Epigenetic’s Science can be used for other types of diseases and conditions, such as Parkinson’s, arthritis, Multiple Sclerosis, and even cancer. Of course, these studies are very small so we do not have much of a sense of what they will mean for human health. Still, it’s an exciting and very promising prospect. Just think, one day you might have the ability to grow your own cells for immune system support and energy generation; essentially creating your very own drug factory!