Epigenetic’s Science is composed by award winning writer, Raoul Pedretta. Great bye, genetically encoded genes… the first book in the exciting new field of epigenetic biology for general readers. The surging new science of epigenetic genetics offers a veritable cornucopia of new insights into our own bodies and minds – some unsettling, some comforting. The assumption of Epigenetic’s Science is that environmental exposures can have long lasting effects on cellular function. Some of these effects are not so easy to reverse and the authors describe how”epigenetic inheritance” can lead to such disorders as cancer, Alzheimer’s disease and Parkinson’s. They also clarify the surprising effect of”epigenetic pollution,” environmental contaminants which are not detected by regular testing and that can cause severe health issues.
Like all living systems, cells are constantly changing and grow, divide and die. All cells need a constant supply of energy, and this procedure is initiated by a process called”mimetic induction”. Through natural selection, favorable mutations accumulate over generations, and when they get together, these cells form a type of cellular memory, or methylation state. This methylation state is passed between generations and decides how cells in one family will behave in response to environmental challenges and how those cells will respond when similar challenges arise in another household member.
When methylation is induced in a cell, the result can be a whole gamut of changes on the cell surface and in the biochemical pathways inside the cell. This causes alterations in gene function and a corresponding response on the body. There are a number of ways in which Epigenetic’s Science presents the science of Epigenetics. For example, each chapter contains an informative section covering among the most common Epigenetic changes that exist in all of us: puberty. The chapters comprise;”Growthal Sensitivity,””Mutations at Birth,”” hormonal changes,””perinatal development,””adolescent-onset diabetes,” and”nutrition.” I enjoyed each of them and found them to be quite interesting and educational.
As you know, during adolescence, the body increases its production of estrogen (in anticipation of future pregnancy), and in turn, produces DHT (which stands for”dihydrotestosterone”). DHT then binds to the hair follicles, which makes it difficult for nutrients to reach the roots. This causes baldness in men and a condition called”male pattern baldness.” Interestingly, this is not the only cause of hair loss, since there are other environmental and genetic factors that contribute to hair loss. Epigenetic science goes a step further and suggests that these other causes of hair loss may also be affected by methylation, so future research may shed even more light on Epigenetic’s Science.
The next topic that Epigenetic’s Science touches on is the effect that diet has on the body. In particular, Epigenetic’s Science goes into detail concerning the impact that diet has on rats, rodents, and other organisms. To begin with, one interesting finding was that when the worm C. elegans was given a high fat diet, it became diabetic and obese. Interestingly, the laboratory animals also lost muscle mass, which is suggestive of insulin resistance. In another experiment, the lab animals were put on a particular sort of diet where they only received food that contained carbohydrates; they lost body fat fairly rapidly.
So as to understand what is happening here, you have to take a look at the Epigenetic’s Science methodology. Fundamentally, they are growing yeast in laboratory cultures and watching what happens. When the yeast grows to a certain point, it will replicate and thus create a new generation of yeast cells. In cases like this, the creation of cells was used to study insulin resistance, something that we humans possess.
Of course, there are other Epigenetic’s Science techniques they use, such as gene regulation and the study of cancerous tumors. In fact, they have recently established a successful clinical trial where they’re trying to treat Alzheimer’s disease in mice. As exciting as that may seem, it is not your regular normal cancer therapy. This study shows they are able to manipulate and regulate cells and stop the growth of cancerous tumors.
Besides diabetes, Epigenetic’s Science may be used for other types of diseases and conditions, such as Parkinson’s, arthritis, Multiple Sclerosis, and even cancer. Of course, these studies are extremely small so we do not have much of a sense of what they will mean for human health. Still, it’s an exciting and very promising prospect. Just think, one day you might be able to grow your own cells for immune system support and energy production; essentially creating your very own drug factory!