Epigenetic’s Science is written by award winning writer, Raoul Pedretta. Great bye, genetically encoded genes… the first book in the exciting new field of epigenetic biology for general readers. The surging new science of epigenetic genetics offers a veritable cornucopia of new insights into our own bodies and minds – some unsettling, some comforting. The premise of Epigenetic’s Science is the fact that environmental exposures can have long lasting effects on cellular function. Some of these effects are not so easy to reverse and the authors describe how”epigenetic inheritance” can lead to such disorders as cancer, Alzheimer’s disease and Parkinson’s. They also describe the surprising effect of”epigenetic pollution,” environmental contaminants that aren’t detected by standard testing and that could cause serious health problems.
Like all living systems, cells are constantly changing and grow, divide and die. All cells require a continuous supply of energy, and this process is initiated by a process called”mimetic induction”. Through natural selection, favorable mutations accumulate over generations, and when they get together, these cells form a type of cellular memory, or methylation state. This methylation state is passed on between generations and decides how cells in one family will act in response to environmental challenges and how those cells will respond when similar challenges arise in a different household member.
When methylation is induced in a cell, the result can be a whole gamut of changes on the cell surface and in the biochemical pathways inside the cell. This results in alterations in gene function and a corresponding response on the body. There are a number of ways that Epigenetic’s Science presents the science of Epigenetics. By way of instance, each chapter contains an informative section covering among the most frequent Epigenetic changes which occur in all people: puberty. The chapters comprise;”Growthal Sensitivity,””Mutations in Birth,”” hormonal changes,””perinatal development,””adolescent-onset diabetes,” and”nutrition.” I enjoyed each of them and found them to be very interesting and educational.
As you know, during adolescence, the body increases its production of estrogen (in anticipation of future pregnancy), and then, produces DHT (which stands for”dihydrotestosterone”). DHT subsequently binds to the hair follicles, making it difficult for nutrients to reach the roots. This causes baldness in a condition called”male pattern baldness.” Interestingly, this isn’t the only cause of hair loss, since there are other genetic and environmental factors that contribute to hair loss. Epigenetic science goes a step further and suggests that these other causes of hair loss may also be affected by methylation, so future study may shed more light on Epigenetic’s Science.
The next topic that Epigenetic’s Science touches on is the effect that diet has on the body. Specifically, Epigenetic’s Science goes into detail concerning the effect that diet has on mice, worms, and other organisms. To begin with, one interesting finding was that when the worm C. elegans has been given a high fat diet, it became obese and diabetic. Interestingly, the laboratory animals also lost muscle mass, which is suggestive of insulin resistance. In another experiment, the laboratory animals were put on a special sort of diet where they just received food that contained carbohydrates; they lost body weight fairly rapidly.
In order to understand what’s going on here, you must have a look at the Epigenetic’s Science methodology. Fundamentally, they’re growing yeast in laboratory cultures and watching what happens. After the yeast grows to a certain point, it is going to replicate and thus create a new production of yeast cells. In cases like this, the generation of cells has been used to study insulin resistance, something that we humans have.
Needless to say, there are other Epigenetic’s Science techniques that they use, such as gene regulation and the study of cancerous tumors. In actuality, they’ve recently launched a successful clinical trial in which they’re trying to treat Alzheimer’s disease in mice. As exciting as that may sound, it’s not your everyday normal cancer therapy. This study shows they are able to manipulate and regulate cells and halt the growth of cancerous tumors.
Besides diabetes, Epigenetic’s Science can be used for other types of diseases and ailments, such as Parkinson’s, arthritis, Multiple Sclerosis, and even cancer. Needless to say, these studies are extremely small so we do not have much of a sense of what they will mean for human health. Still, it’s an exciting and very promising prospect. Just think, one day you might have the ability to grow your own cells for immune system support and energy production; essentially creating your own drug factory!