Epigenetic’s Science is composed by award winning author, Raoul Pedretta. Great bye, genetically encoded genes… the first book in the exciting new field of epigenetic biology for general readers. The surging new science of epigenetic genetics offers a veritable cornucopia of new insights into our own bodies and minds – some unsettling, some comforting. The premise of Epigenetic’s Science is the fact that environmental exposures can have long lasting effects on cellular function. Some of these effects aren’t so easy to reverse and the authors describe how”epigenetic inheritance” can result in such illnesses as cancer, Alzheimer’s disease and Parkinson’s. They also clarify the surprising effect of”epigenetic pollution,” environmental contaminants that aren’t detected by regular testing and that can cause serious health problems.
Like all living systems, cells are constantly changing and grow, divide and die. All cells need a constant supply of energy, and this procedure is initiated by a process referred to as”mimetic induction”. Through natural selection, positive mutations accumulate over generations, and when they get together, these cells form a sort of cellular memory, or methylation state. This methylation state is passed on between generations and determines how cells in one family will behave in response to environmental challenges and how those cells will respond when similar challenges arise in another household member.
When methylation is induced in a cell, the result may be a whole gamut of changes on the cell surface and in the biochemical pathways within the cell. This results in alterations in gene function and a corresponding reaction physically. There are a number of ways in which Epigenetic’s Science presents the science of Epigenetics. For instance, each chapter contains an informative section addressing one of the most common Epigenetic changes that exist in all of us: puberty. The chapters include;”Growthal Sensitivity,””Mutations in Birth,”” hormonal changes,””perinatal development,””adolescent-onset diabetes,” and”nutrition.” I enjoyed each of these and found them to be very interesting and educational.
As you know, during adolescence, the body increases its production of estrogen (in anticipation of future pregnancy), and in turn, produces DHT (which stands for”dihydrotestosterone”). DHT then binds to the hair follicles, making it difficult for nutrients to reach the roots. This causes baldness in men and a condition called”male pattern baldness.” Interestingly, this is not the only cause of hair loss, since there are other environmental and genetic factors that contribute to hair loss. Epigenetic science goes a step further and suggests that these other causes of hair loss may also be affected by methylation, so future study may shed more light on Epigenetic’s Science.
The next topic that Epigenetic’s Science touches on is the effect that diet has on the body. Specifically, Epigenetic’s Science goes into detail concerning the effect that diet has on mice, worms, and other organisms. To begin with, one interesting finding was that when the worm C. elegans has been given a high fat diet, it became obese and diabetic. Interestingly, the lab animals also lost muscle mass, which is suggestive of insulin resistance. In another experiment, the lab animals were put on a special sort of diet where they just received food that contained carbohydrates; they lost body weight fairly quickly.
So as to understand what’s happening here, you must have a look at the Epigenetic’s Science methodology. Fundamentally, they’re growing yeast in lab cultures and watching what happens. After the yeast grows to a certain point, it is going to replicate and thus create a new production of yeast cells. In cases like this, the generation of cells was used to study insulin resistance, something that we humans possess.
Of course, there are additional Epigenetic’s Science techniques that they use, including gene regulation and the study of cancerous tumors. In actuality, they have recently established a successful clinical trial in which they are trying to treat Alzheimer’s disease in mice. As exciting as that may sound, it’s not your regular normal cancer therapy. This study shows they are able to manipulate and regulate cells and stop the growth of cancerous tumors.
In addition to diabetes, Epigenetic’s Science may be used for other types of diseases and conditions, such as Parkinson’s, arthritis, Multiple Sclerosis, and even cancer. Needless to say, these studies are very small so we do not have much of a sense of what they will mean for human health. Still, it’s an exciting and very promising prospect. Just think, one day you could have the ability to grow your own cells for immune system support and energy production; essentially creating your own drug factory!