Epigenetic’s Science is written by award winning author, Raoul Pedretta. Good bye, genetically encoded genes… the first book in the exciting new field of epigenetic biology for general readers. The surging new science of epigenetic genetics provides a veritable cornucopia of new insights into our bodies and minds – some unsettling, some reassuring. The premise of Epigenetic’s Science is that environmental exposures can have long lasting effects on cellular function. Some of these effects aren’t very easy to reverse and the authors describe how”epigenetic inheritance” can lead to such illnesses as cancer, Alzheimer’s disease and Parkinson’s. They also describe the surprising effect of”epigenetic pollution,” environmental contaminants which are not detected by regular testing and that could cause serious health problems.
Like all living systems, cells are constantly changing and grow, divide and die. All cells require a constant supply of energy, and this process is initiated by a process referred to as”mimetic induction”. Through natural selection, positive mutations accumulate over generations, and if they get together, these cells form a type of cellular memory, or methylation state. This methylation state is passed on between generations and determines how cells in 1 family will act in response to environmental challenges and how those cells will react when similar challenges arise in another household member.
When methylation is induced in a cell, the result can be a whole gamut of changes on the cell surface and in the biochemical pathways inside the cell. This results in alterations in gene function and a corresponding response physically. There are a number of ways that Epigenetic’s Science presents the science of Epigenetics. For example, each chapter contains an informative section addressing one of the most common Epigenetic changes which exist in all people: puberty. The chapters comprise;”Growthal Sensitivity,””Mutations in Birth,”” hormonal changes,””perinatal development,””adolescent-onset diabetes,” and”nutrition.” I enjoyed each of them and found them to be quite interesting and educational.
As you know, during adolescence, the body increases its production of estrogen (in anticipation of future pregnancy), and then, produces DHT (which stands for”dihydrotestosterone”). DHT subsequently binds to the hair follicles, making it difficult for nutrients to reach the roots. This causes baldness in men and a condition called”male pattern baldness.” Interestingly, this isn’t the only cause of hair loss, since there are other genetic and environmental factors that contribute to hair loss. Epigenetic science goes a step further and suggests that these other causes of hair loss may also be influenced by methylation, so future study might shed more light on Epigenetic’s Science.
The next topic that Epigenetic’s Science touches on is the impact that diet has on the body. Specifically, Epigenetic’s Science goes into detail concerning the impact that diet has on rats, rodents, and other organisms. To start with, one interesting finding was that when the worm C. elegans was given a high fat diet, it became diabetic and obese. Interestingly, the lab animals also lost muscle mass, which is indicative of insulin resistance. In another experiment, the laboratory animals were put on a particular type of diet where they just received food that contained carbohydrates; they lost body fat fairly quickly.
In order to understand what’s going on here, you have to take a look at the Epigenetic’s Science methodology. Basically, they are growing yeast in lab cultures and watching what happens. When the yeast grows to a certain point, it will replicate and thus create a new generation of yeast cells. In this case, the creation of cells has been used to study insulin resistance, something that we humans have.
Needless to say, there are additional Epigenetic’s Science techniques they use, including gene regulation and the analysis of cancerous tumors. In fact, they have recently established a successful clinical trial in which they are attempting to treat Alzheimer’s disease in mice. As exciting as that may sound, it is not your everyday normal cancer therapy. This study shows that they are able to manipulate and regulate cells and stop the growth of cancerous tumors.
In addition to diabetes, Epigenetic’s Science can be used for other types of diseases and ailments, such as Parkinson’s, arthritis, Multiple Sclerosis, and even cancer. Of course, these studies are very small so we do not have much of a sense of what they will mean for human health. Still, it’s an exciting and very promising prospect. Just think, one day you might be able to grow your own cells for immune system support and energy production; essentially creating your own drug factory!