Epigenetic’s Science is written by award winning writer, Raoul Pedretta. Great bye, genetically encoded genes… the first book in the exciting new field of epigenetic biology for general readers. The surging new science of epigenetic genetics offers a veritable cornucopia of new insights into our bodies and minds – some unsettling, some comforting. The premise of Epigenetic’s Science is the fact that environmental exposures can have long lasting effects on cellular function. Some of these effects are not so easy to reverse and the authors describe how”epigenetic inheritance” can result in such illnesses as cancer, Alzheimer’s disease and Parkinson’s. They also describe the surprising effect of”epigenetic pollution,” environmental contaminants that are not detected by standard testing and that can cause serious health issues.
Like all living systems, cells are constantly changing and grow, divide and die. All cells require a continuous supply of energy, and this process is initiated by a process called”mimetic induction”. Through natural selection, positive mutations accumulate over generations, and if they get together, these cells form a type of cellular memory, or methylation state. This methylation state is passed on between generations and determines how cells in 1 family will act in response to environmental challenges and how those cells will react when similar challenges arise in a different family member.
When methylation is induced in a cell, the result can be a whole gamut of changes on the cell surface and in the biochemical pathways inside the cell. This results in alterations in gene function and a corresponding reaction physically. There are a number of ways in which Epigenetic’s Science presents the science of Epigenetics. For instance, each chapter includes an informative section covering among the most common Epigenetic changes which exist in all people: puberty. The chapters include;”Growthal Sensitivity,””Mutations at Birth,”” hormonal changes,””perinatal development,””adolescent-onset diabetes,” and”nutrition.” I enjoyed each of them and found them to be very interesting and educational.
As you know, during adolescence, the body increases its production of estrogen (in anticipation of future pregnancy), and in turn, produces DHT (which stands for”dihydrotestosterone”). DHT then binds to the hair follicles, making it difficult for nutrients to reach the roots. This causes baldness in a condition known as”male pattern baldness.” Interestingly, this is not the only cause of hair loss, as there are other environmental and genetic factors that contribute to hair loss. Epigenetic science goes a step further and suggests that these other causes of hair loss may also be influenced by methylation, so future research may shed even more light on Epigenetic’s Science.
The next topic that Epigenetic’s Science touches on is the effect that diet has on the body. Specifically, Epigenetic’s Science goes into detail concerning the impact that diet has on rats, rodents, and other organisms. To begin with, one interesting finding was that when the worm C. elegans was given a high fat diet, it became obese and diabetic. Interestingly, the lab animals also lost muscle mass, which is suggestive of insulin resistance. In another experiment, the laboratory animals were put on a particular sort of diet where they just received food which contained carbohydrates; they lost body weight fairly rapidly.
In order to understand what’s going on here, you must take a look at the Epigenetic’s Science methodology. Fundamentally, they’re growing yeast in laboratory cultures and watching what happens. When the yeast grows to a certain point, it is going to replicate and thus create a new generation of yeast cells. In cases like this, the creation of cells has been used to study insulin resistance, something that we humans have.
Of course, there are other Epigenetic’s Science techniques that they use, including gene regulation and the study of cancerous tumors. In actuality, they have recently launched a successful clinical trial where they’re attempting to treat Alzheimer’s disease in mice. As exciting as that may seem, it is not your regular normal cancer treatment. This study shows they are able to manipulate and regulate cells and stop the growth of cancerous tumors.
Besides diabetes, Epigenetic’s Science can be used for other types of diseases and conditions, such as Parkinson’s, arthritis, Multiple Sclerosis, and even cancer. Of course, these studies are extremely small so we do not have much of a sense of what they will mean for human health. Still, it is an exciting and very promising prospect. Just think, one day you could have the ability to grow your own cells for immune system support and energy generation; essentially creating your own drug factory!